Quick Gun Murugun is a western spoof with attitude, featuring outlandish songs, outrageous melodrama and crazy action sequences including a classic duel in a traffic jam. The film tells the story of Quick Gun Murugun - a South Indian karmic cowboy whose duty is to protect and cows. When faced with a world-conquering arch villain restaurant owner who wants to create the ultimate McDosa chain using beef, Quick Gun enters into an epic battle of vegetarianism vs. non-vegetarianism that spans time and space, from a small South Indian village to an Indian heaven and then finally to a cosmopolitan Mumbai across 15 years.

Aamir Ali lives a middle-classed lifestyle in Mumbai along with his dad, Rashid; mom, Taranum; three sisters: Nargis, Shabana, and Falak; and a brother, Jameel. After his dad passes away, Aamir re-locates to Britain, studies, obtains a medical degree, and returns home. Upon arrival at Mumbai Airport, he is hassled by the Customs Officer and his baggage is searched several times. Finally, he is permitted to leave. Outside the airport he is approached by two men on a motorbike, and one of them hands him a cellphone. Aamir accepts the cellphone and thus begins his nightmare that will propel him all the way to Dongri, then to Bhendi Bazar, where he will be given a red suitcase containing cash. He will be told that he must deliver this suitcase at another location within a specified time or else his family will all be killed. Aamir agrees to do so but before he could even arrive at the location...